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運用光纖式粒子電漿共振感測器之動力學常數估算方法「Method for obtaining binding kinetic rate constants using fiber optic particle plasmon resonance (FOPPR) sensor」

專利國別: 美國  發表日期: 2017-03-21 14:29:29  最後修改: 2017-07-14 11:03:24

項目 內容
本校案號 P102007A
發明人 王少君、周禮君、張廷州、吳昭慶
所屬院 理學院
所屬系所 化學暨生物化學系所
類型 發明
申請號 14/063,763
申請日期 2013-10-25
公告號 US 2014-0051188 A1
公告/公開日期 2014-02-20
證書號 US9,506,861B2
核准日期 2016-11-09
國際分類號 G01N 21/552 (20140101); G01N 21/55 (20140101); G01N 21/27 (20060101); G01N 21/77 (20060101)
專利權期間 2013/10/25~2033/10/25
專利摘要 A method for obtaining the binding kinetic rate constants using fiber optic particle plasmon resonance (FOPPR) sensor, suitable for a test solution with two or more concentrations, which employs the following major steps: providing one FOPPR sensor instrument system, obtaining optical time-resolved signal intensities starting at the initial time to the steady state of the two or more regions, substituting the measured signal intensity values into the formula which is derived by using the pseudo-first order rate equation model. In addition, this method measures the temporal signal intensity evolution under static conditions as the samples are quickly loaded. As a result, unlike the conventional device where the sample is continuously infused, the method is able to measure the association and dissociation rate constants of which the upper bounds are not limited by the sample flow rate.
專利權人 國立中正大學