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磁性金奈米聚集探針、其製造方法與使用其的生物粒子檢測方法「MAGNETIC NANOAGGREGATE-EMBEDDED BEAD, MANUFACTURING METHOD THEREOF AND BIOPARTICLE DETECTION METHOD USING THE SAME」

專利國別: 美國  瀏覽人次: 627  發表日期: 2020-12-23 14:41:18  最後修改: 2020-12-23 14:41:18

項目 內容
本校案號 P105020A
發明人 周禮君、顏詩穎
所屬院 理學院
所屬系所 化學暨生物化學系所
類型 發明
申請號 15/648,102
申請日期 2017-07-12
公開號 US 2018/0200296 A1
公開日期 2018-07-19
證書號 US 10,722,534 B2
核准日期 2020-07-28
國際分類號 A61K-033/00(2006.01);A61K-033/38(2006.01);A61K-038/02(2006.01);G01N-033/58(2006.01);G01N-033/543(2006.01);B82Y-005/00(2011.01);A61K-047/52(2017.01);A61K-047/69(2017.01)
專利權期間 2017.07.12~2037.07.12 (延長322天至2038.05.30)
專利摘要 A magnetic nanoaggregate-embedded bead (NAEB), a manufacturing method thereof and a bioparticle detection method using the same are disclosed. The magnetic NAEB has a protective nanoshell, noble metal nanoparticles, Raman reporter molecules and at least one magnetic nanoparticle. The protective nanoshell covers the noble metal nanoparticles, the Raman reporter molecules and the at least one magnetic nanoparticle. The noble metal nanoparticles, the Raman reporter molecules and the at least one magnetic nanoparticle form a magnetic nanoaggregate. Preferably, a chemical modification is performed on the magnetic NAEB, such that at least one targeting molecule is formed on an outer wall of the protective nanoshell, wherein a type of the targeting molecule is corresponding to a type of the bioparticle to be detected.
專利權人 國立中正大學

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