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專利國別 |
美國 |
發表日期 |
2015-05-20 16:32:09 |
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本校案號 |
P101031A |
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專利名稱 |
血紅蛋白轉譯後修飾之偵測方法「ANALYTICAL METHOD OF POST-TRANSLATIONAL MODIFICATIONS IN HEMOGLOBIN」 |
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發明人 |
陳皓君、陳育進 |
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所屬院 |
理學院 |
提案單位 |
化學暨生物化學系所
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類型 |
發明 |
專利權人 |
國立中正大學 |
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申請號 |
13/929,548 |
申請日期 |
2013-06-27 |
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公開號 |
US 2014-0255964 A1 |
公開日期 |
2014-09-11 |
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證書號 |
US 8,906,605 B2 |
核准日期 |
2014-12-09 |
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國際分類號 |
C12Q-001/00(2006.01) |
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專利權期間 |
2013.06.27~2033.06.27 |
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專利摘要 |
An analytical method of post-translational modifications in hemoglobin is disclosed. The analytical method comprises the steps of providing a blood comprising the hemoglobin with post-translational modification of nitration, nitrosylation, or oxidation; performing an extraction process to the blood by an organic solvent; quantifying the hemoglobin by a fluorescent spectrometry; hydrolyzing the hemoglobin into a plurality of peptides by an enzyme; and using a nanoflow liquid chromatography-nanospray ionization tandem mass spectrometry to characterize and quantify the post-translational modifications of the hemoglobin. |
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圖示 |
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