專利國別

  美國   

發表日期

2015-07-28 16:44:03

本校案號

P97003A

專利名稱

藉由一涉及量身訂作的表觀基因體修飾的方法來治療一與異常的基因低度甲基化有關聯的疾病或病況「TREATMENT OF A DISEASE OR A CONDTION ASSOCIATED WITH ABERRANT GENE HYPOMETHYLATION BY A METHOD INVOLVING TAILORED EPIGENOMIC MODIFICATION」

發明人

呂昱瑋、蕭淑惠、黃慧明

所屬院

理學院

提案單位

生命科學系所

類型

發明

專利權人

國立中正大學

申請號

12/135,565

申請日期

2008-06-09

公開號

US 2009-0306191 A1

公開日期

2009-12-10

證書號

US 9,023,819 B2

核准日期

2015-05-05

國際分類號

A61K-048/00(2006.01)

專利權期間

2008.06.09~2028.06.09(延長1133天至2031.07.17)

專利摘要

Disclosed herein is a method for treating a subject having or suspected of having a disease or condition associated with aberrant hypomethylation of one or more genes in the subject, the method involving a tailored epigenomic modification of the subject using methylated polynucleotides directed to hypomethylated genes in the subject. Also disclosed herein is a medicinal composition for treating a subject having or suspected of having a disease or condition associated with aberrant hypomethylation of one or more genes in the subject, the composition including methylated polynucleotides directed to hypomethylated genes in the subject, so as to result in a tailored epigenomic modification of the subject upon administration.

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