專利國別

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發表日期

2018-07-03 15:41:39

本校案號

P94017A

專利名稱

經調節因子連結修飾之血紅素組成物「MODIFIED HEMOGLOBIN WITH ALLOSTERIC EFFECTOR CONJUGATED」

發明人

黃光策、林延霖

所屬院

工學院

提案單位

化學工程學系暨研究所

類型

發明

專利權人

國立中正大學

申請號

11/515,863

申請日期

2006-09-06

公開號

US 2008-0064855 A1

公開日期

2008-03-13

證書號

US 7,795,401 B2

核准日期

2010-09-14

國際分類號

A61K-035/14(2006.01)

專利權期間

2006.09.06~2026.09.06(延長910天至2029.03.04)

專利摘要

The present invention relates generally to a modified hemoglobin with an allosteric effector conjugated which is capable of dynamically regulating the efficiency of oxygen release. The hemoglobin composition provided in the present invention is utilizing maleimide-Polyethylene glycol-N-hydroxysuccinimidyl as a linker to crossbridge the peptide comprising SEQ ID NO: 1 to the surface of a hemoglobin, and hence, it is able to decrease the oxygen affinity through the characteristic of the peptide which could enter into the central cavity formed between .beta.- chains of hemoglobin under an appropriate oxygen concentration.

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